C1orf64 antibody (C-Term)

Catalog No. ABIN6991843

Product Details anti-C1orf64 Antibody

Target: C1orf64 (C1ORF64) (Chromosome 1 Open Reading Frame 64 (C1ORF64))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1orf64 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: ERRF Antibody is affinity chromatography purified via peptide column.

Immunogen: ERRF antibody was raised against a 15 amino acid peptide near the carboxy terminus of human ERRF . The immunogen is located within the last 50 amino acids of ERRF.

Isotype: IgG

Application Details

Application Notes: ERRF Antibody can be used for detection of ERRF by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ERRF Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ERRF antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for C1orf64

Target: C1orf64 (C1ORF64) (Chromosome 1 Open Reading Frame 64 (C1ORF64))

Alternative Name: ERRF (C1ORF64 Products)

Synonyms: ERRF antibody, RP11-5P18.4 antibody, steroid receptor associated and regulated protein antibody, SRARP antibody

Background: ERRF Antibody: The estrogen receptor-related factor (ERRF) is a recently identified protein whose expression is upregulated in multiple cell lines and primary breast cancer tumors. Increased ERRF expression was significantly associated with ER or progesterone receptor (PR) positivity even in HER2-negative tumors. This higher ERRF expression correlated with better disease-free survival and overall survival. In two ER-positive breast cancer cell lines, knockdown of ERRF suppressed cell growth in vitro and tumorigenesis in xenograft models, suggesting that ERRF plays a role in estrogen-ER-mediated breast cancer cell growth and may thus be a potential therapeutic target.

Molecular Weight: Predicted: 19 kDa

Observed: 15 kDa

Gene ID: 149563

NCBI Accession: NP_849162

UniProt: Q8NEQ6