GABARAP antibody (N-Term)

Catalog No. ABIN6991865

Product Details anti-GABARAP Antibody

Target: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABARAP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Multiple isoforms of GABARAP exist due to alternative splicing events.

Purification: GABARAP Antibody is affinity chromatography purified via peptide column.

Immunogen: GABARAP antibody was raised against a 19 amino acid peptide near the amino terminus of human GABARAP. The immunogen is located within the first 50 amino acids of GABARAP.

Isotype: IgG

Application Details

Application Notes: GABARAP antibody can be used for detection of GABARAP by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GABARAP Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GABARAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for GABARAP

Target: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Alternative Name: GABARAP (GABARAP Products)

Synonyms: GABARAP antibody, ATG8A antibody, GABARAP-a antibody, MM46 antibody, gabarap antibody, mg:bb02b03 antibody, GABA type A receptor-associated protein antibody, gamma-aminobutyric acid receptor-associated protein antibody, GABA(A) receptor-associated protein a antibody, gamma-aminobutyric acid receptor associated protein antibody, GABARAP antibody, LOC5568843 antibody, Gabarap antibody, gabarapa antibody

Background: GABARAP Antibody: Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.

Molecular Weight: Predicted: 13kDa

Observed: 15 kDa

Gene ID: 11337

NCBI Accession: NP_009209

UniProt: O95166

Pathways: Autophagy