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BimEL antibody (N-Term)

Reactivity: Rat, Human, Mouse WB, ELISA, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991882
  • Target See all BimEL products
    BimEL
    Binding Specificity
    AA 20-70, N-Term
    Reactivity
    Rat, Human, Mouse
    Host
    • 2
    Rabbit
    Clonality
    • 2
    Polyclonal
    Conjugate
    • 2
    This BimEL antibody is un-conjugated
    Application
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    Bim EL antibody is human and mouse reactive. Multiple isoforms of Bim are known to exist, this antibody only detects the Bim EL isoform.
    Purification
    Bim EL Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Bim EL antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Bim. The immunogen is located within amino acids 20 - 70 of Bim EL.
    Isotype
    IgG
  • Application Notes
    Bim EL antibody can be used for detection of Bim EL by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Bim EL Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    Bim EL antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    BimEL
    Alternative Name
    Bim EL (BimEL Products)
    Background
    Bim EL Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim, also known as Bcl-2-like protein 11, is a pro-apoptotic member of this family and interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Multiple isoforms of Bim are known to exist, with Bim EL being the longest isoform (1,2).
    Molecular Weight
    Predicted: 22 kDa

    Observed: 24 kDa
    Gene ID
    10018
    NCBI Accession
    NP_619527
    UniProt
    O43521
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