T-Bet antibody (C-Term)

Catalog No. ABIN6991904

Product Details anti-T-Bet Antibody

Target: T-Bet

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Bet antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: TBX21 antibody is human and mouse reactive.

Purification: TBX21 Antibody is affinity chromatography purified via peptide column.

Immunogen: TBX21 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human TBX2. The immunogen is located within the last 50 amino acids of TBX21 .

Isotype: IgG

Application Details

Application Notes: TBX21 antibody can be used for detection of TBX21 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TBX21 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TBX21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for T-Bet

Target: T-Bet

Alternative Name: TBX21 (T-Bet Products)

Synonyms: T-PET antibody, T-bet antibody, TBET antibody, TBLYM antibody, TBT1 antibody, Tbet antibody, Tblym antibody, T-box 21 antibody, TBX21 antibody, Tbx21 antibody

Background: TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box (1,2). Members of this family include transcription factors involved in the regulation of developmental processes (2). Studies in mouse and humans show that TBX21 is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (1,3). Expression of the human ortholog also correlates with interferon-gamma expression in Th1 and natural killer cells, suggesting a TBX21 may play a role in initiating Th1 lineage development from naive Th precursor cells. (3).

Molecular Weight: Predicted: 59 kDa

Observed: 55kDa

Gene ID: 30009

NCBI Accession: NP_037483

UniProt: Q9UL17