AIMP1 antibody (C-Term)

Catalog No. ABIN6991919

Product Details anti-AIMP1 Antibody

Target: AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))

Binding Specificity: AA 240-290, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIMP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: AIMP1 antibody is human, mouse and rat reactive. At least two isoforms of AIMP1 are known to exist, this antibody will recognize both isoforms. AIMP1 antibody is predicted to not cross-react with AIMP2.

Purification: AIMP1 antibody is affinity chromatography purified via peptide column.

Immunogen: AIMP1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human AIMP1. The immunogen is located within amino acids 240 - 290 of AIMP1.

Isotype: IgG

Application Details

Application Notes: AIMP1 antibody can be used for detection of AIMP1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human, mouse, and rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: AIMP1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: AIMP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for AIMP1

Target: AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))

Alternative Name: AIMP1 (AIMP1 Products)

Synonyms: EMAP2 antibody, EMAPII antibody, HLD3 antibody, SCYE1 antibody, p43 antibody, wu:fa95a05 antibody, zgc:154081 antibody, AIMP1 antibody, 9830137A06Rik antibody, AIMP1/p43 antibody, Emap2 antibody, Scye1 antibody, scye1 antibody, aminoacyl tRNA synthetase complex interacting multifunctional protein 1 antibody, aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 antibody, aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 S homeolog antibody, AIMP1 antibody, aimp1 antibody, Aimp1 antibody, aimp1.S antibody

Background: AIMP1 (Endothelial monocyte-activating polypeptide II, EMAP2) is a proinflammatory cytokine for monocytes and granulocytes (1). It is specifically induced by apoptosis and is involved in the control of angiogenesis, inflammation, and wound healing (1,2). AIMP1 was identified as one of three auxiliary factors of the mammalian aminoacyl tRNA synthetase (ARS) complex. It binds and facilitates the catalytic reaction of arginyl-tRNA synthetase (2,3). Recent studies show that CD23 plays an essential role in the AIMP1-induced immune response and might be a target in the treatment of inflammatory diseases (4).

Molecular Weight: Predicted: 46 kDa

Observed: 36 kDa

Gene ID: 9255

NCBI Accession: NP_001135888

UniProt: Q12904