OLIG1 antibody (N-Term)

Catalog No. ABIN6991988

Product Details anti-OLIG1 Antibody

Target: OLIG1 (Oligodendrocyte Transcription Factor 1 (OLIG1))

Binding Specificity: AA 50-100, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OLIG1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: OLIG1 antibody is human specific. It is predicted to not cross-react with other members of the OLIG family of proteins.

Purification: OLIG1 antibody is affinity chromatography purified via peptide column.

Immunogen: OLIG1 antibody was raised against an 18 amino acid peptide near the amino terminus of human OLIG1. The immunogen is located within amino acids 50 - 100 of OLIG1.

Isotype: IgG

Application Details

Application Notes: OLIG1 antibody can be used for detection of OLIG1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: OLIG1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: OLIG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for OLIG1

Target: OLIG1 (Oligodendrocyte Transcription Factor 1 (OLIG1))

Alternative Name: OLIG1 (OLIG1 Products)

Synonyms: OLIG1 antibody, BHLHB6 antibody, BHLHE21 antibody, AI836478 antibody, AW494459 antibody, Bhlhb6 antibody, Olg-1 antibody, Oligo1 antibody, bHLHe21 antibody, Olg1 antibody, oligodendrocyte transcription factor 1 antibody, OLIG1 antibody, Olig1 antibody

Background: The oligodendrocyte transcription factors 1 and 2 (OLIG1 and OLIG2, respectively) make up part of basic helix-loop-helix (bHLH) family of transcription factors that are specifically expressed in zones of the neuroepithelium from which oligodendrocyte precursors emerge (1). Both OLIG1 and OLIG2 genes are downstream targets of Sonic hedgehog and are expressed exclusively in the central nervous system (2). OLIG1 is first expressed in the dorsal portion of the p3 progenitor domain of the ventral neural tube while OLIG2 is first observed in the ventral most p3 domain (2). OLIG1 has been shown to be a SMAD cofactor involved in cell motility induced by transforming growth factor-beta (TGF-beta) (3).

Molecular Weight: Predicted: 30 kDa

Observed: 29 kDa

Gene ID: 116448

NCBI Accession: NP_620450

UniProt: Q8TAK6