ANGPTL3 antibody (C-Term)

Catalog No. ABIN6992023

Product Details anti-ANGPTL3 Antibody

Target: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANGPTL3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: ANGPTL3 antibody is human, mouse and rat reactive. ANGPTL3 antibody is predicted not to cross-react with other ANGPTL family proteins.

Purification: ANGPTL3 antibody is affinity chromatography purified via peptide column.

Immunogen: ANGPTL3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human ANGPTL3. The immunogen is located within the last 50 amino acids of ANGPTL3.

Isotype: IgG

Application Details

Application Notes: ANGPTL3 antibody can be used for detection of ANGPTL3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ANGPTL3 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ANGPTL3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ANGPTL3

Target: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Alternative Name: ANGPTL3 (ANGPTL3 Products)

Synonyms: fb60e11 antibody, fb66h02 antibody, wu:fb60e11 antibody, wu:fb66h02 antibody, zgc:111943 antibody, ANGPTL3 antibody, LOC100230785 antibody, ANG-5 antibody, ANGPT5 antibody, ANL3 antibody, FHBL2 antibody, hypl antibody, angiopoietin-like 3 antibody, angiopoietin like 3 antibody, angptl3 antibody, ANGPTL3 antibody, Angptl3 antibody

Background: The angiopoietin-related protein 3 (ANGPTL3) is a member of a family of secreted proteins that function in angiogenesis (1). ANGPTL3 is processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis (2,3). Recent experiments have shown that a deficiency of ANGPTL3 is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids, suggesting that ANGPTL3 may also play a role in modulating glucose metabolism (4).

Molecular Weight: Predicted: 51 kDa

Observed: 53 kDa

Gene ID: 27329

NCBI Accession: NP_055310

UniProt: Q9Y5C1