SHBG antibody (AA 220-270)

Catalog No. ABIN6992049

Product Details anti-SHBG Antibody

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Binding Specificity: AA 220-270

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHBG antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: SHBG antibody is human, mouse, and rat reactive. At least three isoforms of SHBG are known to exist, this antibody will detect all three isoforms.

Purification: SHBG antibody is affinity chromatography purified via peptide column.

Immunogen: SHBG antibody was raised against a 16 amino acid peptide near the center of human SHBG. The immunogen is located within amino acids 220 - 270 of SHBG.

Isotype: IgG

Application Details

Application Notes: SHBG antibody can be used for detection of SHBG by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SHBG antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SHBG antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for SHBG

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Alternative Name: SHBG (SHBG Products)

Synonyms: ABP antibody, SBP antibody, TEBG antibody, Abpa antibody, shbgl antibody, wu:fb66h07 antibody, wu:fd55b08 antibody, zgc:123063 antibody, shbg antibody, sex hormone binding globulin antibody, sex hormone-binding globulin antibody, sex hormone binding globulin L homeolog antibody, SHBG antibody, Shbg antibody, shbg antibody, shbg.L antibody

Background: SHBG is a steroid binding protein that was first described as a plasma protein secreted by the liver and is thought to participate in the regulation of steroid responses. SHBG transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers (1). Low plasma SHBG levels are associated with obesity, abdominal adiposity, metabolic syndrome, and predict the development of type 2 diabetes (2,3). Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus (4).

Molecular Weight: Predicted: 25, 26, 31, 32, 38, 44 kDa

Observed: 35 kDa

Gene ID: 6462

NCBI Accession: NP_001031

UniProt: P04278

Pathways: Hormone Transport