NINJ1 antibody (C-Term)

Catalog No. ABIN6992062

Product Details anti-NINJ1 Antibody

Target: NINJ1 (Ninjurin 1 (NINJ1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NINJ1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: NINJ1 antibody is human, mouse and rat reactive.

Purification: NINJ1 antibody is affinity chromatography purified via peptide column.

Immunogen: NINJ1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human NINJ1. The immunogen is located within the last 50 amino acids of NINJ1.

Isotype: IgG

Application Details

Application Notes: NINJ1 antibody can be used for detection of NINJ1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NINJ1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NINJ1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for NINJ1

Target: NINJ1 (Ninjurin 1 (NINJ1))

Alternative Name: NINJ1 (NINJ1 Products)

Synonyms: nin1 antibody, MGC79511 antibody, ninjurin antibody, NIN1 antibody, NINJURIN antibody, AU024536 antibody, ninjurin 1 antibody, ninjurin 1 L homeolog antibody, NINJ1 antibody, ninj1 antibody, ninj1.L antibody, Ninj1 antibody

Background: Ninjurin-1 (NINJ1) is a homophilic adhesion molecule that is strongly induced in dorsal root ganglion (DRG) and Schwann cells following nerve injury and promotes neurite outgrowth of DRG neurons (1,2), suggesting that NINJ1 may play a role in nerve regeneration. NINJ1 is transcriptionally regulated by p53 and is induced by DNA damage in a p53-dependent manner. A deficiency of NINJ1 increases p53 expression, suppresses cell proliferation, but enhances apoptosis and premature senescence in a p53-dependent manner as well as radiation-induced cell mortality (3).

Molecular Weight: Predicted: 17 kDa

Observed: 16 kDa

Gene ID: 4814

NCBI Accession: NP_004139

UniProt: Q92982