KIRREL2 antibody (C-Term)

Catalog No. ABIN6992064

Product Details anti-KIRREL2 Antibody

Target: KIRREL2 (Kin of IRRE Like 2 (Drosophila) (KIRREL2))

Binding Specificity: AA 550-600, C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIRREL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: KIRREL2 antibody is human, mouse and rat reactive. At least five isoforms are are known to exist. This antibody is predicted to not cross-react with other members of the KIRREL protein family.

Purification: KIRREL2 antibody is affinity chromatography purified via peptide column.

Immunogen: KIRREL2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KIRREL2. The immunogen is located within amino acids 550 - 600 of KIRREL2.

Isotype: IgG

Application Details

Application Notes: KIRREL2 antibody can be used for detection of KIRREL2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KIRREL2 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KIRREL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for KIRREL2

Target: KIRREL2 (Kin of IRRE Like 2 (Drosophila) (KIRREL2))

Alternative Name: KIRREL2 (KIRREL2 Products)

Synonyms: nlg1 antibody, neph3 antibody, filtrin antibody, FILTRIN antibody, NEPH3 antibody, NLG1 antibody, C330019F22Rik antibody, cb33 antibody, kirrel3 antibody, sb:cb33 antibody, si:dkey-29g23.1 antibody, wu:fb74e02 antibody, kirre like nephrin family adhesion molecule 2 antibody, kin of IRRE like 2 (Drosophila) antibody, kirre like nephrin family adhesion molecule 3, like antibody, kirrel2 antibody, KIRREL2 antibody, Kirrel2 antibody, kirrel3l antibody

Background: KIRREL2, also known as nephrin-like 3, is a type I transmembrane protein belonging to the immunoglobulin superfamily of cell adhesion molecules (1). KIRREL2 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues (1,2). KIRREL2 has been found to be expressed in beta cells of pancreatic islets and is involved in the regulation of both glomerular and neural development (3,4). Downregulation of KIRREL2 is implicated in several proteinuric diseases (4,5).

Molecular Weight: Predicted: 64, 70, 78 kDa

Observed: 70 kDa

Gene ID: 84063

NCBI Accession: NP_954649

UniProt: Q6UWL6