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JAGN1 antibody (C-Term)

JAGN1 Reactivity: Human, Mouse, Rat ELISA, WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6992170
  • Target See all JAGN1 Antibodies
    JAGN1 (Jagunal Homolog 1 (JAGN1))
    Binding Specificity
    C-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 5
    Rabbit
    Clonality
    • 5
    Polyclonal
    Conjugate
    • 2
    • 1
    • 1
    • 1
    This JAGN1 antibody is un-conjugated
    Application
    • 4
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    JAGN1 antibody is human, mouse and rat reactive. At least four isoforms of JAGN1 are known to exist, this antibody will detect all but isoform 2.
    Purification
    JAGN1 antibody is affinity chromatography purified via peptide column.
    Immunogen
    JAGN1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAGN1. The immunogen is located within the last 50 amino acids of JAGN1.
    Isotype
    IgG
    Top Product
    Discover our top product JAGN1 Primary Antibody
  • Application Notes
    JAGN1 antibody can be used for detection of JAGN1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    JAGN1 antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    JAGN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    JAGN1 (Jagunal Homolog 1 (JAGN1))
    Alternative Name
    JAGN1 (JAGN1 Products)
    Synonyms
    GL009 antibody, 5830427H10Rik antibody, zgc:101070 antibody, wu:fb07b07 antibody, zgc:101045 antibody, jagunal homolog 1 antibody, jagunal homolog 1 L homeolog antibody, jagunal homolog 1a antibody, jagunal homolog 1b antibody, JAGN1 antibody, Jagn1 antibody, jagn1.L antibody, jagn1a antibody, jagn1b antibody
    Background
    JAGN1 is the human ortholog of a gene originally identified in Drosophila melanogaster. It is a transmembrane protein that functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Individuals with mutations in the JAGN1 gene causes aberrant myeloid cell homeostasis and severe congenital neutropenia (SCN) (1). JAGN1-mutant granulocytes are characterized by ultrastructural defects, aberrant N-glycosylation of multiple proteins, and increased apoptosis (1). Mice lacking this gene could not mount and efficient neutrophil-dependent immune response to a human fungal pathogen (2).
    Molecular Weight
    Predicted: 20 kDa

    Observed: 25 kDa
    Gene ID
    84522
    NCBI Accession
    NP_115881
    UniProt
    Q8N5M9
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