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CARD16 antibody

CARD16 Reactivity: Human ELISA, WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7244684
  • Target See all CARD16 Antibodies
    CARD16 (Caspase Recruitment Domain Family, Member 16 (CARD16))
    Reactivity
    Human
    Host
    • 21
    • 4
    • 1
    Rabbit
    Clonality
    • 24
    • 2
    Polyclonal
    Conjugate
    • 12
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CARD16 antibody is un-conjugated
    Application
    • 15
    • 12
    • 9
    • 4
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Antigen affinity purification
    Immunogen
    Synthetic peptide of human CARD16
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.1 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CARD16 (Caspase Recruitment Domain Family, Member 16 (CARD16))
    Alternative Name
    CARD16 (CARD16 Products)
    Synonyms
    COP antibody, COP1 antibody, PSEUDO-ICE antibody, caspase recruitment domain family member 16 antibody, CARD16 antibody
    Background
    Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
    Molecular Weight

    Observed_MW: Refer to figures

    Calculated_MW: 23 kDa

    UniProt
    Q5EG05
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