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IGHA1 antibody

IGHA1 Reactivity: Human IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7246370
  • Target See all IGHA1 products
    IGHA1 (Immunoglobulin Heavy Constant alpha 1 (IGHA1))
    Reactivity
    • 16
    • 2
    • 2
    Human
    Host
    • 13
    • 3
    Rabbit
    Clonality
    • 13
    • 3
    Polyclonal
    Conjugate
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IGHA1 antibody is un-conjugated
    Application
    • 8
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA
    Characteristics
    Polyclonal Antibody
    Purification
    Antigen affinity purification
    Immunogen
    Fusion protein of human IGHA1
    Isotype
    IgG
  • Application Notes
    IHC 1:50-1:300, ELISA 1:5000-1:10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.14 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    IGHA1 (Immunoglobulin Heavy Constant alpha 1 (IGHA1))
    Alternative Name
    IGHA1 (IGHA1 Products)
    Synonyms
    IgA1 antibody, immunoglobulin heavy constant alpha 1 antibody, IGHA1 antibody
    Background
    Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
    UniProt
    P01876
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