Active CASP3 antibody
Reactivity: Human, Mouse, Rat
IF, IHC (p), WB
Host: Mouse
Monoclonal
5A2
unconjugated
-
- Target
- Active CASP3
- Reactivity
- Human, Mouse, Rat
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- Un-conjugated
- Application
- Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- Characteristics
- Monoclonal Antibody
- Purification
- Protein A purification
- Immunogen
- Recombinant Protein
- Clone
- 5A2
- Isotype
- IgG
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anti-Active CASP3 antibody
Reactivity: Human, Mouse, Rat IF, IHC (p), WB Host: Mouse Monoclonal 5A2 unconjugated
anti-Active CASP3 (active) antibodyReactivity: Human, Mouse, Rat IF, IHC (p), WB Host: Mouse Monoclonal 5A2 unconjugated
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- Application Notes
- WB 1:500-1:1000, IHC 1:100-1:200, IF 1:100-1:200
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- Active CASP3
- Background
- Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
- Molecular Weight
- 17 kDa
- UniProt
- P42574
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