GNB3 antibody

Catalog No. ABIN7257427

Product Details anti-GNB3 Antibody

Target: GNB3 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 3 (GNB3))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNB3 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human GNB3 (NP_002066.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GNB3

Target: GNB3 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 3 (GNB3))

Alternative Name: GNB3 (GNB3 Products)

Synonyms: Gnb-3 antibody, MGC68913 antibody, MGC130764 antibody, gnb3 antibody, zgc:73058 antibody, zgc:77780 antibody, wu:fk54b04 antibody, gnb3l antibody, zgc:92641 antibody, G protein subunit beta 3 antibody, guanine nucleotide binding protein (G protein), beta 3 antibody, guanine nucleotide binding protein (G protein), beta polypeptide 3 S homeolog antibody, guanine nucleotide binding protein (G protein), beta polypeptide 3b antibody, guanine nucleotide binding protein (G protein), beta polypeptide 3a antibody, GNB3 antibody, Gnb3 antibody, gnb3.S antibody, gnb3b antibody, gnb3a antibody

Background: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Molecular Weight:

Observed_MW: 37 kDa

Calculated_MW: 32 kDa/37 kDa

Gene ID: 2784

UniProt: P16520

Pathways: Peptide Hormone Metabolism, Myometrial Relaxation and Contraction