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BTK antibody (pTyr223)
BTK
Reactivity: Human, Mouse, Rat
IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-BTK Antibody
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Target
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BTK
(Bruton Agammaglobulinemia tyrosine Kinase (BTK))
Binding Specificity
All epitopes for BTK antibodies
pTyr223
Reactivity
All reactivities for BTK antibodies
Human, Mouse, Rat
Host
All hosts for BTK antibodies
Rabbit
Clonality
All clonalities for BTK antibodies
Polyclonal
Conjugate
All conjugates for BTK antibodies
This BTK antibody is un-conjugated
Application
All applications for BTK antibodies
Immunofluorescence (IF)
Characteristics
Phosphorylated antibody
Purification
Affinity purification
Immunogen
A synthetic phosphorylated peptide around Y223 of human Btk (NP_000052.1).
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
IF 1:20-1:100
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for BTK
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Target
BTK
(Bruton Agammaglobulinemia tyrosine Kinase (BTK))
Alternative Name
Btk (BTK Products )
Synonyms
BTK antibody, atk antibody, bpk antibody, xla antibody, imd1 antibody, agmx1 antibody, psctk1 antibody, AGMX1 antibody, AT antibody, ATK antibody, BPK antibody, IMD1 antibody, PSCTK1 antibody, XLA antibody, AI528679 antibody, xid antibody, Bruton tyrosine kinase antibody, Bruton agammaglobulinemia tyrosine kinase antibody, BTK antibody, btk antibody, Btk antibody
Background
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
695
UniProt
Q06187
Pathways
Fc-epsilon Receptor Signaling Pathway , Hormone Transport , Activation of Innate immune Response , Regulation of Leukocyte Mediated Immunity , Production of Molecular Mediator of Immune Response , Toll-Like Receptors Cascades , BCR Signaling
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