CD8 antibody (APC)
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- Target See all CD8 Antibodies
- CD8
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Reactivity
- Human, Non-Human Primate
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD8 antibody is conjugated to APC
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Application
- Flow Cytometry (FACS)
- Specificity
- The mouse monoclonal antibody LT8 recognizes an extracellular epitope of CD8, a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. This antibody blocks Leu2 binding.
- Purification
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogen
- human blood lymphocytes
- Clone
- LT8
- Isotype
- IgG1
- Top Product
- Discover our top product CD8 Primary Antibody
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anti-CD8 (CD8) (AA 51-150) antibody
CD8 Reactivity: Human, Mouse, Rat FACS, IHC (fro), WB, ELISA, IHC (p), IF (cc), IF (p) Host: Rabbit Polyclonal unconjugated
anti-CD8 (CD8) antibody (PE)CD8 Reactivity: Human FACS Host: Mouse Monoclonal MEM-31 PE
anti-CD8 (CD8) (AA 22-187) antibodyCD8 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-CD8 (CD8) antibodyCD8 Reactivity: Human FACS, IP, CyTOF Host: Mouse Monoclonal MEM-31 unconjugated
anti-CD8 (CD8) antibody (PE)CD8 Reactivity: Cat FACS Host: Mouse Monoclonal fCD8 PE
anti-CD8 (CD8) antibodyCD8 Reactivity: Human IHC, WB, IP, ELISA Host: Rabbit Monoclonal 3C3 unconjugated Recombinant Antibody
anti-CD8 (CD8) antibody (Biotin)CD8 Reactivity: Human FACS, IP Host: Mouse Monoclonal MEM-31 Biotin
anti-CD8 (CD8) antibody (FITC)CD8 Reactivity: Human FACS Host: Mouse Monoclonal MEM-31 FITC
anti-CD8 (CD8) antibody (PerCP)CD8 Reactivity: Human FACS Host: Mouse Monoclonal MEM-31 PerCP
anti-CD8 (CD8) antibody (APC)CD8 Reactivity: Human FACS Host: Mouse Monoclonal MEM-31 APC
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- Application Notes
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- Restrictions
- For Research Use only
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- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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- Target
- CD8
- Alternative Name
- CD8 (CD8 Products)
- Synonyms
- CD8 antibody, Leu2 antibody, MAL antibody, p32 antibody, CD8a molecule antibody, CD8A antibody
- Background
- The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.,p32, LEU2
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