Adenomatous Polyposis Coli (APC) (AA 2790-2843) antibody

Details for Product No. ABIN702550, Supplier: Log in to see
Antigen
  • dp2
  • dp3
  • fap
  • fpc
  • xapc
  • dp2.5
  • AI047805
  • AU020952
  • AW124434
  • CC1
  • Min
  • mAPC
  • BTPS2
  • DP2
  • DP2.5
  • DP3
  • GS
  • PPP1R46
  • RATAPC
  • APC1
  • APC, WNT signaling pathway regulator
  • adenomatous polyposis coli
  • adenomatous polyposis coli protein, putative
  • adenomatosis polyposis coli
  • adenomatous polyposis coli L homeolog
  • APC
  • apc
  • Smp_139190
  • Apc
  • apc.L
Alternatives
anti-Human Adenomatous Polyposis Coli antibody for Immunocytochemistry
Epitope
AA 2790-2843
27
26
20
17
14
9
9
4
4
4
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
176
105
74
10
7
6
5
4
3
2
2
1
Host
Rabbit
158
38
15
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
10
10
7
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
149
101
60
53
48
29
25
24
15
4
3
2
1
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide derived from human APC
Isotype IgG
Purification Purified by Protein A.
Alternative Name Adenomatous Polyposis Coli (APC Antibody Abstract)
Background

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Subcellular location: Cytoplasm

Synonyms: GS, DP2, DP3, BTPS2, DP2.5, PPP1R46, Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 2.5, APC

Gene ID 324
UniProt P25054
Pathways WNT Signaling, Stem Cell Maintenance, Cell-Cell Junction Organization
Application Notes IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Adenomatous Polyposis Coli (APC) (AA 2790-2843) antibody (ABIN702550) Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-APC/Adenomato...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Adenomatous Polyposis Coli (APC) (AA 2790-2843) antibody (ABIN702550) Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-APC/Adenomato...
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