RGD1310159 antibody, 2410021P16Rik antibody, acyl-CoA dehydrogenase family, member 10 antibody, acyl-CoA dehydrogenase family member 10 antibody, acyl-CoA dehydrogenase family member 10 L homeolog antibody, acyl-Coenzyme A dehydrogenase family, member 10 antibody, Acad10 antibody, ACAD10 antibody, LOC588060 antibody, acad10.L antibody, acad10 antibody, LOC100179340 antibody, LOC100632488 antibody
Background
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. ACAD10 has significant activity towards the branched-chain substrates R and S, 2 methyl-C15-CoA and is highly expressed in fetal but not adult brain. This pattern of expression is similar to that of LCAD, another ACAD previously shown to be involved in long branched chain fatty acid metabolism.