Thymidine Phosphorylase antibody (AA 121-220) (HRP)

Catalog No. ABIN704450

Product Details anti-Thymidine Phosphorylase Antibody (HRP)

Target: Thymidine Phosphorylase (TYMP)

Binding Specificity: AA 121-220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thymidine Phosphorylase antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Thymidine Phosphorylase

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Thymidine Phosphorylase

Target: Thymidine Phosphorylase (TYMP)

Alternative Name: TP/thymidine phosphorylase (TYMP Products)

Synonyms: ECGF antibody, ECGF1 antibody, MEDPS1 antibody, MNGIE antibody, MTDPS1 antibody, PDECGF antibody, TP antibody, hPD-ECGF antibody, 2900072D10Rik antibody, Ecgf1 antibody, PD-ECGF antibody, Pdgfec antibody, typh antibody, thymidine phosphorylase antibody, thymidine phosphorylase DeoA antibody, AMP phosphorylase antibody, Thymidine phosphorylase antibody, TYMP antibody, Tymp antibody, deoA antibody, Dd586_0614 antibody, Kvar_4413 antibody, NMAG_RS19330 antibody, Snov_1187 antibody, Fbal_2856 antibody, Ftrac_2071 antibody, Intca_1216 antibody, ARCVE_RS10415 antibody, Sphch_4174 antibody, Sinme_3461 antibody, METOK_RS06355 antibody, Mesop_1831 antibody, typh antibody

Background:

Synonyms: ECGF 1, PDEGF, ECGF1, Endothelial cell growth factor 1, Endothelial cell growth factor 1 platelet derived, Gliostatin, hPD ECGF, MNGIE, PD ECGF, PDECGF, PDEGF, Platelet derived endothelial growth factor, TdRPase, TP, TYMP, Thymidine Phosphorylase, TYPH_HUMAN, TdRPase.

Background: In the presence of inorganic orthophosphate, the platelet-derived endothelial growth factor (PD-ECGF) thymidine phosphorylase (TP) (gliostatin) catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.

Gene ID: 1890

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2