CUBN antibody

Catalog No. ABIN7073601

Product Details anti-CUBN Antibody

Target: CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CUBN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse Cubilin

Application Details

Application Notes: WB (M,R) 1:500-1:1000, IHC/IF (H,M,R) 1:650-1:1300

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for CUBN

Target: CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))

Alternative Name: Cubilin (CUBN Products)

Synonyms: GP280 antibody, IFCR antibody, MGA1 antibody, AA408369 antibody, AL022750 antibody, D2Wsu88e antibody, gp280 antibody, cubilin antibody, cubilin (intrinsic factor-cobalamin receptor) antibody, LOC411053 antibody, CUBN antibody, cubn antibody, Cubn antibody

Background: Cubilin is an endocytic receptor that lacks a classical transmembrane region. It is a multidomain receptor that contains an amino terminal 110 residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch of 27 CUB domains. Cubilin acts as a receptor for intrinsic factor-vitamin B12 complexes. Cubilin is located within the epithelium of intestine and kidney. Mutations in Cubilin may play a role in autosomal recessive megaloblastic anemia also known as Imerslund-Grasbeck's disease, which causes intestinal malabsorption of vitamin B12.

Molecular Weight: 399 kDa

Gene ID: 65969

NCBI Accession: NP_001074553

UniProt: Q9JLB4

Pathways: Metabolism of Steroid Hormones and Vitamin D, Lipid Metabolism