CG6897 antibody, Dmel\\CG6897 antibody, zgc:101616 antibody, C13orf34 antibody, 6720463M24Rik antibody, AI317232 antibody, RGD1309522 antibody, c13orf34 antibody, C12H13orf34 antibody, aurora borealis antibody, bora, aurora kinase A activator antibody, protein aurora borealis antibody, bora, aurora kinase A activator S homeolog antibody, bora antibody, Tsp_06066 antibody, Bora antibody, BORA antibody, bora.S antibody
Background
Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm.