Sarcomeric alpha Actinin antibody
Reactivity: Mouse, Rat
WB, IEM, IF, IHC
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Sarcomeric alpha Actinin
- Reactivity
- Mouse, Rat
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB), Immunoelectron Microscopy (IEM), Immunofluorescence (IF), Immunohistochemistry (IHC)
- Cross-Reactivity
- Rat
- Purification
- Affinity purification
- Immunogen
- KLH conjugated Synthetic peptide corresponding to Mouse alpha Actinin 2
-
- Application Notes
- WB (M,R) 1:2000, IHC/IF ,IEM (M,R) 1:500-1:1000/1:2000/1:50
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
-
- Target
- Sarcomeric alpha Actinin
- Background
- The primary function of alpha-actinin 2 is to crosslink filamentous actin molecules and titin molecules from adjoining sarcomeres at Z-discs, a function that is modulated by phospholipids. It is clear from studies by Hampton etal. that this crosslinking can assume a variety of conformations, with preferences for 60° and 120° angles. Alpha-actinin 2 also functions in docking signaling molecules at Z-discs, and additional studies have also implicated alpha-actinin 2 in the binding of cardiac ion channels, Kv1.5 in particular.
- Molecular Weight
- 104 kDa
- Gene ID
- 11472
- NCBI Accession
- NP_150371
- UniProt
- Q9JI91
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