ULBP2 antibody

Catalog No. ABIN7076145

Product Details anti-ULBP2 Antibody

Target: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULBP2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Human ULBP2

Application Details

Application Notes: WB (H) 1:500- 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for ULBP2

Target: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Alternative Name: ULBP2 (ULBP2 Products)

Synonyms: N2DL2 antibody, RAET1H antibody, UL16 binding protein 2 antibody, NKG2D ligand 2-like antibody, ULBP2 antibody, LOC100355436 antibody

Background: ULBP2 is a human ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. The interaction with UL16 blocks the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. ULBP2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.

Molecular Weight: 37 kDa

Gene ID: 80328

NCBI Accession: NP_079493

UniProt: Q9BZM5