CD73 antibody (APC-Cy7)

Catalog No. ABIN7077433

Product Details anti-CD73 Antibody (APC-Cy7)

Target: CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD73 antibody is conjugated to APC-Cy7

Application: Flow Cytometry (FACS)

Characteristics: The clone AD2, a mouse monoclonal antibody recognizes a 70kD glycophosphatidylinositol (GPI)-linked 5'nucleotidase (or 5'-Ecto-nucleotidase) cell surface antigen known as CD73. It is widely expressed on various immune as well as non-immune cells including T and B cells, mesenchymal stem cells, follicular dendritic cells, endothelial cells, epithelial cells, etc. CD73 catalyzes the conversion of extracellular nucleosides to adenosine and modulates immune responses. Administration of CD73 inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells.

Purification: Purified

Purity: >95 %

Grade: GMP Grade

Immunogen: Pre-B leukemia cell line

Clone: AD2

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for CD73

Target: CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

Alternative Name: CD73 (NT5E Products)

Synonyms: CALJA antibody, CD73 antibody, E5NT antibody, NT antibody, NT5 antibody, NTE antibody, eN antibody, eNT antibody, zgc:63784 antibody, NT5E antibody, MGC114869 antibody, PSPTO2277 antibody, 2210401F01Rik antibody, AI447961 antibody, Nt5 antibody, 5'-nucleotidase ecto antibody, 5'-nucleotidase, ecto (CD73) antibody, 5'-nucleotidase antibody, 5' nucleotidase, ecto antibody, NT5E antibody, nt5e antibody, nt5e.S antibody, PSPTO_2277 antibody, CBU_1233 antibody, MCA1322 antibody, Nt5e antibody

Background: The clone AD2, a mouse monoclonal antibody recognizes a 70kD glycophosphatidylinositol (GPI)-linked 5'nucleotidase (or 5'-Ecto-nucleotidase) cell surface antigen known as CD73. It is widely expressed on various immune as well as non-immune cells including T and B cells, mesenchymal stem cells, follicular dendritic cells, endothelial cells, epithelial cells, etc. CD73 catalyzes the conversion of extracellular nucleosides to adenosine and modulates immune responses. Administration of CD73 inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells.

Gene ID: 4907

UniProt: P21589

Pathways: Synaptic Membrane, Ribonucleoside Biosynthetic Process