fb16c04 antibody, wu:fb16c04 antibody, zgc:77714 antibody, MGC68415 antibody, CTDSP2 antibody, OS4 antibody, PSR2 antibody, SCP2 antibody, AI586070 antibody, D10Ertd73e antibody, OS-4 antibody, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 antibody, CTD small phosphatase 2 L homeolog antibody, CTD small phosphatase 2 antibody, ctdsp2 antibody, ctdsp2.L antibody, CTDSP2 antibody, Ctdsp2 antibody
Background
Synonyms:NIF2, OS4, SCP2 Background:Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain(CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.