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DDIT3 antibody
DDIT3
Reactivity: Human
WB, ELISA
Host: Mouse
Monoclonal
5H7
unconjugated
Product Details anti-DDIT3 Antibody
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Target
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DDIT3
(DNA-Damage-Inducible Transcript 3 (DDIT3))
Reactivity
All reactivities for DDIT3 antibodies
Human
Host
All hosts for DDIT3 antibodies
Mouse
Clonality
All clonalities for DDIT3 antibodies
Monoclonal
Conjugate
All conjugates for DDIT3 antibodies
This DDIT3 antibody is un-conjugated
Application
All applications for DDIT3 antibodies
Western Blotting (WB), ELISA
Purification
Protein A+G purification
Purity
≥95 % as determined by SDS-PAGE
Immunogen
DNA-damage-inducible transcript 3
Clone
5H7
Isotype
IgG2a
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Application Details
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Application Notes
WB: 1:500-1:5000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
-20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Expiry Date
12 months
Target Details for DDIT3
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Target
DDIT3
(DNA-Damage-Inducible Transcript 3 (DDIT3))
Alternative Name
CHOP, GADD153 (DDIT3 Products )
Synonyms
chop antibody, Xchop antibody, cebpz antibody, chop10 antibody, gadd153 antibody, CHOP-10 antibody, CHOP10 antibody, CHOP antibody, Chop10 antibody, Gadd153 antibody, CEBPZ antibody, GADD153 antibody, DNA damage inducible transcript 3 antibody, DNA-damage inducible transcript 3 antibody, DNA damage inducible transcript 3 L homeolog antibody, ddit3 antibody, Ddit3 antibody, DDIT3 antibody, ddit3.L antibody
Background
Synonyms:C/EBP homologous protein, C/EBP homologous protein 10, CEBPZ, CHOP, CHOP 10, CHOP, GADD153, CHOP10, DDIT 3, DDIT3, GADD153 Background:CHOP, also known as GADD153 or DDIT3, is a highly conserved gene in both the structural and regulatory regions to hamster gene.Imposed by unfolded and malfolded proteins, CHOP is significantly induced by ER stress, deficiency of CHOP prevents cell from ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C/EBP and LAP by forming a heterodimer. It may play an important role in the malignant transformation of nevus to melanoma.
Molecular Weight
30 kDa
UniProt
P35638
Pathways
Regulation of Muscle Cell Differentiation , ER-Nucleus Signaling , Skeletal Muscle Fiber Development , Cell RedoxHomeostasis
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