EGLN3 antibody

Catalog No. ABIN7113751

Product Details anti-EGLN3 Antibody

Target: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EGLN3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: egl nine homolog 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:500-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for EGLN3

Target: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Alternative Name: PHD3 (EGLN3 Products)

Synonyms: zgc:77019 antibody, wu:fj78a08 antibody, EGLN3 antibody, phd3 antibody, PHD-3 antibody, PHD3 antibody, SM-20 antibody, 2610021G09Rik antibody, AI505553 antibody, AI648162 antibody, Hif-p4h-3 antibody, Phd3 antibody, HIFP4H3 antibody, HIFPH3 antibody, egl-9 family hypoxia-inducible factor 3 antibody, egl-9 family hypoxia inducible factor 3 antibody, egl-9 family hypoxia-inducible factor 3 L homeolog antibody, egln3 antibody, EGLN3 antibody, egln3.L antibody, Egln3 antibody

Background: Synonyms:Egl nine homolog 3, EGLN3, FLJ21620, HIF PH3, HIF prolyl hydroxylase 3, HIFPH3, HPH 1, HPH 3, PHD3 Background:EGLN3, also named as HPH-1, HIF-PH3, HPH-3 and PHD3, is a cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor(HIF) alpha proteins. It hydroxylates a specific proline found in each of the oxygen-dependent degradation(ODD) domains(N-terminal, NODD, and C-terminal, CODD) of HIF1A. It is a regulator of cardiomyocyte and neuronal apoptosis. EGLN3 can be a prognostic marker for gastric cancer.

Molecular Weight: 28kd

UniProt: Q9H6Z9

Pathways: Positive Regulation of Endopeptidase Activity