IFNAR2 antibody

Catalog No. ABIN7115355

This anti-IFNAR2 antibody is a Rabbit Polyclonal antibody detecting IFNAR2 in WB, ELISA and IF. Suitable for Human, Mouse and Rat.

Quick Overview for IFNAR2 antibody (ABIN7115355)

Target: IFNAR2 (Interferon alpha/beta Receptor 2 (IFNAR2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNAR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-IFNAR2 Antibody

Purpose: IFNAR2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: interferon(alpha, beta and omega) receptor 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IFNAR2

Target: IFNAR2 (Interferon alpha/beta Receptor 2 (IFNAR2))

Alternative Name: IFNAR2

Background:

Synonyms: Interferon alpha/beta receptor 2 (IFN-R-2, IFN-alpha binding protein, IFN-alpha/beta receptor 2)|Interferon alpha binding protein|Type I interferon receptor 2|IFNAR2|IFNABR|IFNARB

Background: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation(PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1(PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity(PubMed:7759950).

Molecular Weight: 58-66 kDa

Gene ID: 3455

UniProt: P48551

Pathways: JAK-STAT Signaling, Hepatitis C