IFITM3 antibody

Catalog No. ABIN7115387

Product Details anti-IFITM3 Antibody

Target: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFITM3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: interferon induced transmembrane protein 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:500-1:3000, IHC: 1:50-1:400, IF: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for IFITM3

Target: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Alternative Name: IFITM3 (IFITM3 Products)

Synonyms: 1110004C05Rik antibody, Cd225 antibody, Cdw217 antibody, DSPA2b antibody, Fgls antibody, IP15 antibody, mil-1 antibody, 1-8U antibody, rat8 antibody, Interferon-induced transmembrane protein 3 antibody, interferon induced transmembrane protein 3 antibody, ifm3 antibody, Ifitm3 antibody, IFITM3 antibody

Background: Synonyms:1 8U, IFITM3, IP15 Background:IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus(SARS-CoV), Marburg virus(MARV) and Ebola virus(EBOV), Dengue virus(DNV), West Nile virus(WNV), human immunodeficiency virus type 1(HIV-1) and vesicular stomatitis virus(VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase(v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Molecular Weight: 14 kDa

Gene ID: 10410

UniProt: Q01628