KLHL22 antibody

Catalog No. ABIN7115599

Product Details anti-KLHL22 Antibody

Target: KLHL22 (Kelch-Like 22 (KLHL22))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLHL22 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: kelch-like 22(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for KLHL22

Target: KLHL22 (Kelch-Like 22 (KLHL22))

Alternative Name: KLHL22 (KLHL22 Products)

Synonyms: 2610318I18Rik antibody, Kelchl antibody, KELCHL antibody, RGD1306288 antibody, kelch-like 22 antibody, kelch like family member 22 antibody, kelch-like family member 22 antibody, Klhl22 antibody, KLHL22 antibody

Background: Synonyms: Background:Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint(SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

Molecular Weight: 72 kDa

Gene ID: 84861

UniProt: Q53GT1