TRPV6 antibody

Catalog No. ABIN7120140

Product Details anti-TRPV6 Antibody

Target: TRPV6 (Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPV6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: transient receptor potential cation channel, subfamily V, member 6

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IP: 1:200-1:1000, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for TRPV6

Target: TRPV6 (Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6))

Alternative Name: TRPV6 (TRPV6 Products)

Synonyms: ecac antibody, trpv5-6 antibody, TRPV6 antibody, trpv6 antibody, CaT antibody, ECaC antibody, ABP/ZF antibody, CAT1 antibody, CATL antibody, ECAC2 antibody, HSA277909 antibody, LP6728 antibody, ZFAB antibody, CAT antibody, CaT1 antibody, Cac antibody, Ecac2 antibody, Otrpc3 antibody, transient receptor potential cation channel, subfamily V, member 6 antibody, transient receptor potential cation channel subfamily V member 6 antibody, trpv6 antibody, TRPV6 antibody, Trpv6 antibody

Background: Synonyms:ABP/ZF, Calcium transport protein 1, CaT L, CaT like, CAT1, CATL, ECAC2, Epithelial calcium channel 2, HSA277909, LP6728, TRPV6, ZFAB Background:Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine(PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin(By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification(PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.

Molecular Weight: 82 kDa,70 kDa

Gene ID: 55503

UniProt: Q9H1D0

Pathways: TCR Signaling