YY1 antibody
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- Target See all YY1 Antibodies
- YY1 (YY1 Transcription Factor (YY1))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This YY1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- Purification
- Immunogen affinity purified
- Purity
- ≥95 % as determined by SDS-PAGE
- Immunogen
- YY1 transcription factor
- Isotype
- IgG
- Top Product
- Discover our top product YY1 Primary Antibody
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- Application Notes
- WB: 1:500-1:5000, IP: 1:200-1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Expiry Date
- 12 months
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- Target
- YY1 (YY1 Transcription Factor (YY1))
- Alternative Name
- YY1 (YY1 Products)
- Synonyms
- yy1-a antibody, FIII antibody, MGC83714 antibody, yy1l antibody, zgc:64207 antibody, YY1 antibody, LOC494431 antibody, xyy1 antibody, delta antibody, nf-e1 antibody, ucrbp antibody, yin-yang-1 antibody, LOC100304682 antibody, ino80s antibody, yy1 antibody, DELTA antibody, INO80S antibody, NF-E1 antibody, UCRBP antibody, YIN-YANG-1 antibody, AW488674 antibody, fb59g10 antibody, wu:fa16g07 antibody, wu:fb59g10 antibody, YY1 transcription factor L homeolog antibody, YY1 transcription factor b antibody, YY1 transcription factor antibody, transcriptional repressor protein YY1 antibody, YY1 transcription factor S homeolog antibody, YY1 transcription factor a antibody, YY2 transcription factor antibody, yy1.L antibody, yy1b antibody, YY1 antibody, yy1 antibody, LOC100304682 antibody, yy1.S antibody, Yy1 antibody, yy1a antibody, YY2 antibody
- Background
- Synonyms:DELTA, Delta transcription factor, INO80 complex subunit S, INO80S, NF E1, UCRBP, Yin and yang 1, YIN YANG 1, YY 1, YY1, YY1 transcription factor Background:Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3', some genes have been shown to contain a longer binding motif allowing enhanced binding, the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein(BMP)-mediated cardiac-specific gene expression(PubMed:15329343). Binds to SMAD binding elements(SBEs)(5'-GTCT/AGAC-3') within BMP response element(BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures(Holliday junctions). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair, proposed to target the INO80 complex to YY1-responsive elements.
- Molecular Weight
- 65 kDa
- Gene ID
- 7528
- UniProt
- P25490
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