LRG1 antibody (AA 30-180)

Catalog No. ABIN7126225

Product Details anti-LRG1 Antibody

Target: LRG1 (Leucine-Rich alpha-2 Glycoprotein 1 (LRG1))

Binding Specificity: AA 30-180

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LRG1 antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: LRG1 (leucine-rich i±2-glycoprotein), also known as LRG, is a 347 amino acid secreted protein that contains 8 LRR (leucine-rich) repeats and one LRRCT domain. The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, cell adhesion and development. Found mainly in plasma, LRG1 is expressed during granulocyte differentiation. The gene that encodes LRG1 consists of nearly 3,000 bases and maps to human chromosome 19p13.3. Chromosome 19 consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families and Fc receptors (FcRs).

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 30-180) of human LRG1 protein (exact sequence is proprietary)

Isotype: IgG2b

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human liver, pancreas or breast.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for LRG1

Target: LRG1 (Leucine-Rich alpha-2 Glycoprotein 1 (LRG1))

Alternative Name: LRG1 (LRG1 Products)

Synonyms: lrg antibody, HMFT1766 antibody, LRG antibody, 1300008B03Rik antibody, 2310031E04Rik antibody, Lrg antibody, Lrhg antibody, si:dkey-90m5.4 antibody, leucine rich alpha-2-glycoprotein 1 antibody, leucine-rich alpha-2-glycoprotein 1 L homeolog antibody, leucine-rich alpha-2-glycoprotein 1 antibody, perilipin-5 antibody, si:dkey-90m5.4 antibody, LRG1 antibody, lrg1.L antibody, Lrg1 antibody, PLIN5 antibody

Background: 1300008B03Rik, 2310031E04Rik, A2GL, HMFT1766, Leucine-rich alpha-2-glycoprotein 1, Leucine-rich alpha-2-glycoprotein precursor, LRG1,LRG1 / Leucine Rich alpha-2-glycoprotein 1
Cellular localisation: Secreted.

Molecular Weight: 38kDa

Gene ID: 116844, 655559

UniProt: P02750

Pathways: Brown Fat Cell Differentiation