Angiotensin I Converting Enzyme 1 antibody

Catalog No. ABIN7126288

The Mouse Monoclonal anti-Angiotensin I Converting Enzyme 1 antibody (Clone ACE-3764) (ABIN7126288) specifically detects Angiotensin I Converting Enzyme 1 in IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for Angiotensin I Converting Enzyme 1 antibody (ABIN7126288)

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Angiotensin I Converting Enzyme 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: ACE-3764

Product Details anti-Angiotensin I Converting Enzyme 1 Antibody

Purpose: Angiotensin I Converting Enzyme (ACE) / CD143 Antibody

Specificity: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.

Cross-Reactivity (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Full-length recombinant human ACE/CD143 protein

Isotype: IgG1, kappa

Application Details

Application Notes:

Known_Application: ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Angiotensin I Converting Enzyme 1

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Alternative Name: ACE

Background:

ACE, ACE1, angiotensin 1 converting enzyme 1, carboxycathepsin, CD143, CD143 antigen, DCP, DCP1, dipeptidyl carboxypeptidase 1, Kininase II, MVCD3, peptidase P, testicular ECA

gastrointestinal system and prostate., Heart, Kidney, Ubiquitously expressed, with highest levels in lung

Molecular Weight: 150kDa

Gene ID: 1636, 298469

UniProt: P12821

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration