Apolipoprotein D antibody (AA 21-119)

Catalog No. ABIN7126542

Product Details anti-Apolipoprotein D Antibody

Target: Apolipoprotein D (APOD)

Binding Specificity: AA 21-119

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Apolipoprotein D antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: Lipids, such as phospholipids, triacylglycerols and cholesterol, are weakly soluble in aqueous solution and therefore are transported by circulation as components of lipoproteins. Lipoproteins are globular particles that consist of a non-polar core of triacylglycerols and cholesteryl esters surrounded by phospholipid, cholesterol and an amphiphilic coating of protein, known as apolipoproteins (apo). These complexes allow the dissolution and shuttling of their non-polar lipid components. At least nine different apolipoproteins are distributed in significant amounts in different human lipoproteins. Apolipoprotein D (apoD) is a member of the lipocalin superfamily of transporter proteins that bind small hydrophobic molecules, including arachidonic acid (AA). The ability of apoD to bind AA implicates it in pathways associated with membrane phospholipid signal transduction and metabolism. apoD expression has been shown to correlate both with cell cycle arrest and with prognosis in several types of malignancy, including central nervous system astrocytomas and medulloblastomas.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Human recombinant APOD protein fragment (around aa21-119) (exact sequence is proprietary)

Isotype: IgG2

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human liver, kidney or spleen.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for Apolipoprotein D

Target: Apolipoprotein D (APOD)

Alternative Name: APOD (APOD Products)

Synonyms: APOD antibody, apod antibody, zgc:153593 antibody, AOPDGN antibody, Apo-D antibody, lipocalin antibody, apolipoprotein D antibody, apolipoprotein Da, duplicate 1 antibody, APOD antibody, CpipJ_CPIJ006492 antibody, CpipJ_CPIJ017615 antibody, CpipJ_CPIJ020105 antibody, apod antibody, apoda.1 antibody, Apod antibody

Background: APO-D protein,Apolipoprotein D / APO-D
Cellular localisation: Secreted.

Molecular Weight: 30kDa

Gene ID: 347, 522555

UniProt: P05090

Pathways: Platelet-derived growth Factor Receptor Signaling