Syndecan 1 antibody (AA 90-250)

Catalog No. ABIN7126924

Product Details anti-Syndecan 1 Antibody

Target: Syndecan 1 (SDC1)

Binding Specificity: AA 90-250

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Syndecan 1 antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: CD138, also designated syndecan-1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. Under normal conditions CD138 is predominantly expressed on mature plasma cells and early preB-cells, while other haematolymphoid cells are negative. Various types of epithelial cells are also CD138 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal and neural tissues are not stained. Among haematolymphoid neoplasms, CD138 is expressed in practically all cases of plasma cell malignancies. Among non-haematolymphoid neoplasms the expression of CD138 is found in various types of carcinoma.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa90-250) of human CD138 protein (exact sequence is proprietary)

Isotype: IgG1

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human tonsil or lymph node.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for Syndecan 1

Target: Syndecan 1 (SDC1)

Alternative Name: SDC1 (SDC1 Products)

Synonyms: CG10497 antibody, CT27296 antibody, Dmel\\CG10497 antibody, Dsyn antibody, Syd antibody, Syn antibody, dSdc antibody, l(2)10608 antibody, sdc antibody, syd antibody, syn antibody, Syn1 antibody, cd138 antibody, synd1 antibody, xSyn1 antibody, syndecan1 antibody, Syndecan-1 antibody, XSyndecan-1 antibody, SDC1 antibody, CD138 antibody, SDC antibody, SYND1 antibody, syndecan antibody, AA408134 antibody, AA409076 antibody, Sstn antibody, Synd antibody, Synd1 antibody, syn-1 antibody, HSPG antibody, SYNDECA antibody, Syndecan antibody, Syndecan antibody, syndecan 1 antibody, Sdc antibody, sdc1 antibody, SDC1 antibody, Sdc1 antibody

Background: Heparan Sulfate Proteoglycan Fibroblast Growth Factor Receptor, SDC1, SYND1, Syndecan Proteoglycan 1, Syndecan-1,CD138 / Syndecan-1 (SDC1) (Plasma Cell Marker)
Cellular localisation: Cell Surface

Molecular Weight: 85kDa

Gene ID: 6382, 224607

UniProt: P18827

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Lipid Metabolism