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STAT5A antibody

STAT5A Reactivity: Human IF, FACS Host: Mouse Monoclonal unconjugated
Catalog No. ABIN7126986
  • Target See all STAT5A Antibodies
    STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
    Reactivity
    • 181
    • 96
    • 70
    • 22
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 162
    • 20
    • 2
    Mouse
    Clonality
    • 153
    • 31
    Monoclonal
    Conjugate
    • 106
    • 10
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    This STAT5A antibody is un-conjugated
    Application
    • 154
    • 66
    • 60
    • 40
    • 39
    • 28
    • 21
    • 16
    • 16
    • 12
    • 10
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS)
    Specificity
    Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96 % homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4- mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.
    Cross-Reactivity (Details)
    Human. Predicted to work with Mouse and Rat.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Protein domain of STAT5A
    Isotype
    IgG2
    Top Product
    Discover our top product STAT5A Primary Antibody
  • Application Notes

    Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa or Jurkat cells.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
    Alternative Name
    STAT5A (STAT5A Products)
    Synonyms
    MGF antibody, STAT5 antibody, AA959963 antibody, Stat5 antibody, STAT5A/MGF antibody, STATA5 antibody, STAT5A antibody, stat5 antibody, stat5b antibody, signal transducer and activator of transcription 5A antibody, signal transducer and activator of transcription 5a antibody, STAT5A antibody, Stat5a antibody, stat5a antibody, LOC100348518 antibody, LOC100716811 antibody
    Background
    Signal transducer and activator of transcription 5A, Transcription factor STAT5A, Mammary gland factor (MGF),STAT5A
    Cellular localisation: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
    Molecular Weight
    64kDa
    Gene ID
    6776, 437058
    UniProt
    P42229
    Pathways
    JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
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