ZBED1 antibody

Catalog No. ABIN7127132

Product Details anti-ZBED1 Antibody

Target: ZBED1 (Zinc Finger, BED-Type Containing 1 (ZBED1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ZBED1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Specificity: ZBED1 (zinc finger BED domain-containing protein 1), also known as ALTE (Ac-like transposable element), DREF or TRAMP, is a 694 amino acid protein that localizes specifically to granular structures within the nucleus. Expressed ubiquitously at low levels and present at higher levels in heart, placenta, spleen and skeletal muscle, ZBED1 is thought to function as a transcription factor that regulates a number of ribosomal protein (RP) encoding genes, thereby playing a role in the cell cycle and in cell proliferation events. ZBED1 contains one BED-type zinc finger and binds specifically to 5'- TGTCG[CT]GA[CT]A-3' DNA regions found in RP promotors. Additionally, ZBED1 binds strongly to the promotor region of Histone H1 (a protein required for the condensation of nucleosomes into higher order structures), subsequently activating H1 transcription.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human ZBED1 protein

Isotype: IgG2a

Application Details

Application Notes:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL),Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or HepG2 cells.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for ZBED1

Target: ZBED1 (Zinc Finger, BED-Type Containing 1 (ZBED1))

Alternative Name: ZBED1 (ZBED1 Products)

Synonyms: ZBED1 antibody, ZBED1P antibody, ALTE antibody, DREF antibody, TRAMP antibody, hDREF antibody, zinc finger BED-type containing 1 antibody, zinc finger, BED-type containing 1 antibody, ZBED1 antibody, zbed1 antibody

Background: Ac like transposable element, ALTE, BED type zinc finger domain containing protein 1, DNA replication related element binding factor, dREF homolog, hDREF, KIAA0785, Putative Ac-like transposable element, TRAMP, ZBED1, Zinc finger BED domain-containing protein 1,ZBED1 / DREF
Cellular localisation: Nucleus. In granular structures.

Molecular Weight: 86kDa

Gene ID: 9189, 131452

UniProt: O96006