Recombinant AIF antibody
Quick Overview for Recombinant AIF antibody (ABIN7127329)
Target
See all AIF (AIFM1) AntibodiesAntibody Type
Reactivity
Host
Clonality
Conjugate
Application
Clone
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Purpose
- AIFM1 Recombinant Monoclonal Antibody
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Cross-Reactivity
- Rat
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Purification
- Affinity-chromatography
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Immunogen
- A synthesized peptide derived from human AIF
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Isotype
- IgG
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anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody
AIFM1 Reactivity: Human, Rat, Mouse, Monkey WB, IHC, ELISA, ICC, FACS Host: Mouse Monoclonal 4E7 unconjugated
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (AA 131-230) antibodyAIFM1 Reactivity: Human, Rat, Mouse, Pig WB, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (AA 103-322) antibodyAIFM1 Reactivity: Human WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (C-Term) antibodyVerified AIFM1 Reactivity: Human, Rat, Mouse, Pig WB, IHC, ELISA, IF Host: Goat Polyclonal unconjugated
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibodyKD Validated AIFM1 Reactivity: Human WB, FACS, IF (p) Host: Rabbit Monoclonal 25GB2810 unconjugated Recombinant Antibody
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (AA 334-613) antibodyAIFM1 Reactivity: Human WB, IHC, IF, IP Host: Rabbit Polyclonal unconjugated
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (C-Term) antibodyAIFM1 Reactivity: Human, Rat, Mouse WB, IHC, IF, ICC, FACS Host: Rabbit Polyclonal unconjugated
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (AA 183-195) antibodyVerified AIFM1 Reactivity: Human, Mouse WB, IHC, ELISA, IF Host: Goat Polyclonal unconjugated
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (AA 70-98), (N-Term) antibodyAIFM1 Reactivity: Human WB, IF, FACS, IHC (p) Host: Rabbit Polyclonal RB22966 unconjugated
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (C-Term) antibodyAIFM1 Reactivity: Human, Rat, Mouse WB, IHC, IF, ICC, FACS Host: Mouse Monoclonal 2I5 unconjugated
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Application Notes
- WB:1:500-1:5000, IHC:1:50-1:200
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))
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Alternative Name
- AIFM1
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Background
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Background: Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Aliases: Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8), AIFM1, AIF PDCD8
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UniProt
- O95831
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Pathways
- Apoptosis, Positive Regulation of Endopeptidase Activity, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Warburg Effect
Target
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