FAM89B antibody

Catalog No. ABIN7129446

Product Details anti-FAM89B Antibody

Target: FAM89B (Family with Sequence Similarity 89, Member B (FAM89B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM89B antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen affinity purification

Immunogen: Fusion protein of Human FAM89B

Isotype: IgG

Application Details

Application Notes: ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FAM89B

Target: FAM89B (Family with Sequence Similarity 89, Member B (FAM89B))

Alternative Name: FAM89B (FAM89B Products)

Synonyms: MTVR1 antibody, 1110021A21Rik antibody, MMTV antibody, Mtvr2 antibody, family with sequence similarity 89 member B antibody, family with sequence similarity 89, member B antibody, FAM89B antibody, Fam89b antibody

Background:

Background: Mtvr1 (mammary tumor virus receptor homolog 1), also known as FAM89B (family with sequence similarity 89, member B), is a 176 amino acid protein that exists as two alternatively spliced isoforms. Belonging to the FAM89 family, Mtvr1 is encoded by a gene that maps to human chromosome 11, which comprises approximately 4 % of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.

Aliases: FAM89B antibody, Lrap25 antibody, Leucine repeat adapter protein 25 antibody

UniProt: Q8N5H3