BCR antibody (pTyr177)

Catalog No. ABIN7138949

Product Details anti-BCR Antibody

Target: BCR (Breakpoint Cluster Region (BCR))

Binding Specificity: pTyr177

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 177 (P-F-Y(p)-V-N) derived from Human Bcr.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BCR

Target: BCR (Breakpoint Cluster Region (BCR))

Alternative Name: BCR (BCR Products)

Synonyms: si:dkey-83d9.7 antibody, zK83D9.7 antibody, BCR antibody, ALL antibody, BCR1 antibody, CML antibody, D22S11 antibody, D22S662 antibody, PHL antibody, 5133400C09Rik antibody, AI561783 antibody, AI853148 antibody, mKIAA3017 antibody, breakpoint cluster region antibody, BCR, RhoGEF and GTPase activating protein antibody, bcr antibody, BCR antibody, Bcr antibody

Background:

Background: GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Sattler M, et al. Mol Cell Biol. 1999 Nov, 19(11): 7473-7480.
Li S et al. EMBO J. 2001 Dec 3, 20(23): 6793-6804.
Million RP, et,al. Mol Cell Biol. 2004 Jun, 24(11): 4685-4695.
Malcolm A. Meyn, et al. . Biol. Chem., Oct 2006, 281: 30907

Aliases: ALL antibody, bcr antibody, BCR/ABL FUSION GENE, INCLUDED antibody, BCR/FGFR1 chimera protein antibody, BCR/FGFR1 FUSION GENE, INCLUDED antibody, BCR/PDGFRA FUSION GENE, INCLUDED antibody, BCR_HUMAN antibody, BCR1 antibody, Breakpoint cluster region antibody, Breakpoint cluster region protein antibody, CML antibody, D22S11 antibody, D22S662 antibody, FGFR1/BCR chimera protein antibody, PHL antibody, Renal carcinoma antigen NY-REN-26 antibody

UniProt: P11274

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling