ZAP7 (pTyr493) antibody

Catalog No. ABIN7139014

Product Details

Target: ZAP7

Binding Specificity: pTyr493

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 493 (S-Y-Y(p)-T-A) derived from Human Zap-70.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: ZAP7

Background:

Background: Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.

Chan AC, et al. (1995) EMBO J, 14(11): 2499-2508
Kong G, et al. (1996) Mol Cell Biol, 16(9): 5026-5035
Salomon AR, et al. (2003)Proc Natl Acad Sci U S A, 100(2): 443-448

Aliases: 70 kDa zeta associated protein antibody, 70 kDa zeta-associated protein antibody, EC 2.7.10.2 antibody, FLJ17670 antibody, FLJ17679 antibody, Selective T cell defect antibody, SRK antibody, STD antibody, Syk related tyrosine kinase antibody, Syk-related tyrosine kinase antibody, Truncated ZAP kinase antibody, Tyrosine protein kinase ZAP70 antibody, Tyrosine-protein kinase ZAP-70 antibody, TZK antibody, ZAP 70 antibody, ZAP70 antibody, ZAP70_HUMAN antibody, Zeta chain associated protein kinase 70kD antibody, Zeta chain associated protein kinase 70 kDa antibody, Zeta chain associated protein kinase 70 kDa isoform 1 antibody, Zeta chain associated protein kinase 70 kDa isoform 2 antibody, Zeta chain of T cell receptor associated protein kinase 70 antibody, Zeta chain TCR associated protein kinase 70kD antibody, Zeta chain TCR associated protein kinase 70 kDa antibody

UniProt: P43403