EPB41 antibody (pTyr418, pTyr660)

Catalog No. ABIN7139042

Product Details anti-EPB41 Antibody

Target: EPB41 (Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41))

Binding Specificity: pTyr418, pTyr660

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPB41 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 660/418 (N-I-Y(p)-I-R)derived from Human EPB41.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EPB41

Target: EPB41 (Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41))

Alternative Name: EPB41 (EPB41 Products)

Synonyms: P4.1R antibody, epb41 antibody, wu:fb70c02 antibody, EPB41 antibody, el1 antibody, 4.1r antibody, 4.1R antibody, EL1 antibody, HE antibody, AI415518 antibody, D4Ertd442e antibody, Elp-1 antibody, Elp1 antibody, Epb41 antibody, mKIAA4056 antibody, erythrocyte membrane protein band 4.1b antibody, erythrocyte membrane protein band 4.1 antibody, erythrocyte membrane protein band 4.1 L homeolog antibody, epb41b antibody, EPB41 antibody, epb41 antibody, epb41.L antibody, Epb41 antibody

Background:

Background:

Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene, the beta-spectrin gene, or the band 3 gene.

Conboy J.G., Proc. Natl. Acad. Sci. U.S.A. 83:9512-9516(1986).
Tang T.K., Adv. Exp. Med. Biol. 241:81-95(1988).
Tang T.K., Proc. Natl. Acad. Sci. U.S.A. 85:3713-3717(1988).

Aliases: 4.1R antibody, 41_HUMAN antibody, Band 4.1 antibody, E41P antibody, EL 1 antibody, EL1 antibody, EL1 gene antibody, Elliptocytosis 1 antibody, Elliptocytosis 1 RH linked antibody, EPB 4.1 antibody, EPB 41 antibody, EPB4.1 antibody, Epb41 antibody, Erythrocyte membrane protein band 4.1 (elliptocytosis 1 RH linked) antibody, Erythrocyte membrane protein band 4.1 antibody, Erythrocyte surface protein band 4.1 antibody, HE antibody, P4.1 antibody, Protein 4.1 antibody, Protein 4.1, red blood cell type antibody

UniProt: P11171