GRK2 antibody (C-Term)

Catalog No. ABIN7140291

The Mouse Monoclonal anti-GRK2 antibody has been validated for WB and ELISA. It is suitable to detect GRK2 in samples from Human.

Quick Overview for GRK2 antibody (C-Term) (ABIN7140291)

Target: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GRK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GRK2 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Dog, Human, Mouse, Pig, Rat

Purification: Affinity purified

Immunogen: Purified recombinant human ADRBK1(C-term.) protein fragments expressed in E.coli.

Isotype: IgG1, IgG1 kappa

Application Details

Application Notes: Recommended dilution:WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine ( pH 7.4, 150 mM NaCl) with 0.2 % sodium azide, 50 %,glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GRK2

Target: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Alternative Name: ADRBK1

Background:

Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1.

Aliases: GRK2, BARK1, BETA-ARK1

UniProt: P25098

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling