PtxA (AA 35-269) antibody

Catalog No. ABIN7353279

Product Details

Target: PtxA

Binding Specificity: AA 35-269

Reactivity: Bordetella pertussis

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Bordetella pertussis

Purification: >95%, Protein G purified

Immunogen: Recombinant Bordetella pertussis Pertussis toxin subunit 1 protein (35-269AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: PtxA

Background:

Background: S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD+ into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.

Aliases: ptxA antibody, BP3783 antibody, Pertussis toxin subunit 1 antibody, PTX S1 antibody, Islet-activating protein S1 antibody, IAP S1 antibody, NAD-dependent ADP-ribosyltransferase antibody, EC 2.4.2.- antibody

UniProt: P04977