26S Proteasome Complex Subunit SEM1 (SEM1) (AA 1-70) antibody (Biotin)

Catalog No. ABIN7142195

Product Details

Target: 26S Proteasome Complex Subunit SEM1 (SEM1)

Binding Specificity: AA 1-70

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 26S proteasome complex subunit SEM1 protein (1-70AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: 26S Proteasome Complex Subunit SEM1 (SEM1)

Alternative Name: SEM1

Background:

Background: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.

Aliases: SEM1 antibody, C7orf76 antibody, DSS1 antibody, SHFDG1 antibody, SHFM1 antibody, 26S proteasome complex subunit SEM1 antibody, 26S proteasome complex subunit DSS1 antibody, Deleted in split hand/split foot protein 1 antibody, Split hand/foot deleted protein 1 antibody, Split hand/foot malformation type 1 protein antibody

UniProt: P60896