PRKAG1 antibody (AA 1-331) (FITC)

Catalog No. ABIN7142669

Product Details anti-PRKAG1 Antibody (FITC)

Target: PRKAG1 (Protein Kinase, AMP-Activated, gamma 1 Non-Catalytic Subunit (PRKAG1))

Binding Specificity: AA 1-331

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRKAG1 antibody is conjugated to FITC

Application: Please inquire

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 5\'-AMP-activated protein kinase subunit gamma-1 protein (1-331AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PRKAG1

Target: PRKAG1 (Protein Kinase, AMP-Activated, gamma 1 Non-Catalytic Subunit (PRKAG1))

Alternative Name: PRKAG1 (PRKAG1 Products)

Synonyms: MGC68503 antibody, zgc:63896 antibody, wu:fa94d09 antibody, wu:fd12h04 antibody, AMPKG antibody, Prkaac antibody, Prkga1 antibody, AA571379 antibody, BB036179 antibody, protein kinase, AMP-activated, gamma 1 non-catalytic subunit S homeolog antibody, protein kinase, AMP-activated, gamma 1 non-catalytic subunit antibody, protein kinase AMP-activated non-catalytic subunit gamma 1 antibody, prkag1.S antibody, prkag1 antibody, PRKAG1 antibody, Prkag1 antibody

Background:

Background: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Aliases: 5' AMP activated protein kinase gamma 1 subunit antibody, 5' AMP activated protein kinase subunit gamma 1 antibody, 5''-AMP-activated protein kinase subunit gamma-1 antibody, AAKG1_HUMAN antibody, AMP activated protein kinase noncatalytic gamma 1 subunit antibody, AMPK gamma 1 chain antibody, AMPK gamma1 antibody, AMPK subunit gamma-1 antibody, AMPKg antibody, MGC8666 antibody, PRKAG 1 antibody, PRKAG1 antibody, Protein kinase AMP activated gamma 1 non catalytic subunit antibody, protein kinase, AMP-activated, noncatalytic gamma-1 antibody

UniProt: P54619

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process, Warburg Effect