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DARC antibody (AA 1-63)

DARC Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7145066
  • Target See all DARC Antibodies
    DARC (Duffy Blood Group, Chemokine Receptor (DARC))
    Binding Specificity
    • 13
    • 12
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-63
    Reactivity
    • 39
    • 10
    • 6
    Human
    Host
    • 30
    • 8
    • 2
    • 2
    Rabbit
    Clonality
    • 35
    • 6
    • 1
    Polyclonal
    Conjugate
    • 24
    • 4
    • 4
    • 4
    • 3
    • 3
    This DARC antibody is un-conjugated
    Application
    • 28
    • 24
    • 9
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Cross-Reactivity
    Human, Mouse
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Atypical chemokine receptor 1 protein (1-63AA)
    Isotype
    IgG
    Top Product
    Discover our top product DARC Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    DARC (Duffy Blood Group, Chemokine Receptor (DARC))
    Alternative Name
    ACKR1 (DARC Products)
    Synonyms
    DARC antibody, FY antibody, ACKR1 antibody, CCBP1 antibody, CD234 antibody, Dfy antibody, GPD antibody, GpFy antibody, WBCQ1 antibody, AA162249 antibody, Ackr1 antibody, ESTM35 antibody, Duffy blood group, chemokine receptor antibody, atypical chemokine receptor 1 (Duffy blood group) antibody, atypical chemokine receptor 1 antibody, DARC antibody, ACKR1 antibody, Ackr1 antibody
    Background

    Background: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes, when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.

    Aliases: ACKR1 antibody, Atypical chemokine receptor 1 antibody, CCBP1 antibody, CD234 antibody, DARC antibody, Dfy antibody, Duffy antigen/chemokine receptor antibody, duffy blood group antibody, Duffy blood group antigen antibody, Duffy blood group chemokine receptor antibody, DUFFY_HUMAN antibody, FY antibody, Fy glycoprotein antibody, Glycoprotein D antibody, GPD antibody, GpFy antibody, Plasmodium vivax receptor antibody, WBCQ1 antibody

    UniProt
    Q16570
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