DARC antibody (AA 1-63) (HRP)
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- Target See all DARC Antibodies
- DARC (Duffy Blood Group, Chemokine Receptor (DARC))
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Binding Specificity
- AA 1-63
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DARC antibody is conjugated to HRP
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Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Atypical chemokine receptor 1 protein (1-63AA)
- Isotype
- IgG
- Top Product
- Discover our top product DARC Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- DARC (Duffy Blood Group, Chemokine Receptor (DARC))
- Alternative Name
- ACKR1 (DARC Products)
- Synonyms
- DARC antibody, FY antibody, ACKR1 antibody, CCBP1 antibody, CD234 antibody, Dfy antibody, GPD antibody, GpFy antibody, WBCQ1 antibody, AA162249 antibody, Ackr1 antibody, ESTM35 antibody, Duffy blood group, chemokine receptor antibody, atypical chemokine receptor 1 (Duffy blood group) antibody, atypical chemokine receptor 1 antibody, DARC antibody, ACKR1 antibody, Ackr1 antibody
- Background
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Background: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes, when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Aliases: ACKR1 antibody, Atypical chemokine receptor 1 antibody, CCBP1 antibody, CD234 antibody, DARC antibody, Dfy antibody, Duffy antigen/chemokine receptor antibody, duffy blood group antibody, Duffy blood group antigen antibody, Duffy blood group chemokine receptor antibody, DUFFY_HUMAN antibody, FY antibody, Fy glycoprotein antibody, Glycoprotein D antibody, GPD antibody, GpFy antibody, Plasmodium vivax receptor antibody, WBCQ1 antibody
- UniProt
- Q16570
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